PPAR相关论文
目的:在痰瘀伏络的理论指导下,通过体内实验探讨参红通络方对动脉粥样硬化的影响及改善动脉粥样硬化进程中受损胞葬的机制,言明参......
2型糖尿病（diabetes mellitus type 2,T2DM）是一种严重且常见的慢性疾病，由复杂的遗传–环境相互作用及肥胖和久坐不动的生活方式等危......
杨梅是一种广受欢迎的水果,果味酸甜适中,既可直接食用,又可加工成杨梅干、酱、蜜饯等,还可酿酒,有止渴、生津、助消化等功能。杨......
为寻找新型的过氧化物酶体增殖物激动剂，将芳香醛、萘丁美酮和对三氟甲基苯胺经Mannich反应直接合成了17个未见文献报道的β-氨基酮......
CYP2C45 mediates the effect of fatty acids on hepatocytes: a link from fatty acids to goose fatty li
Cytochrome P450 (CYPs),a superfamily of hemoproteins,participate in a number of important biological processes.CYP2C45,u......
目的 越来越多的证据表明PPARg信号通路在中枢神经系统内发挥着重要的作用，研究其中枢神经系统内的表达位点和表达细胞类型将大大有......
目的 观察槲皮素-3-o-新橙皮糖苷对L6肌管细胞胰岛素抵抗模型葡萄糖消耗；脂肪酸消耗以及对PPARα；PPARγ； GLUT4表达量的调节作用及其......
Sang-qi Granula Reduces Blood Pressure and Myocardial Fibrosis by Suppressing Inflammatory Responses
Aim: Sang-qi Granula (SQ) is a compound preparation of Chinese medcine and currently used for treatment of hypertension ......
The thiazolidinedione class PPARγ agonists as antidiabetic agents are restricted in clinical use because of the side ef......
0.引言环氧合酶(cyclooxygenase,cox)是花生四烯酸生物合成前列腺素的限速酶。包括cox-1和cox-2两种亚型,其中cox-2的过度表达与胃......
体外研究已经证实,黄芪与莪术配伍的益气活血疗法能显著抑制胃癌细胞的生物学活性,并可能通过NF-κB/PPARγ信号通路调控COX-2的表......
过氧化物酶体增殖物激活受体(PPAR)家族在维持脂肪组织和调节产热活性中起着关键作用,在白色脂肪棕色化过程中扮演重要的角色.研究......
Upregulation of the PPAR signaling pathway and accumulation of lipids are related to the morphologic
Goldfish comprise around 300 different strains with drastically altered and aesthetical morphologies making them suitabl......
Hepatoprotective effects of tocotrienols on lipid peroxidation,antioxidant scavenging enzymes, and P
Scope Prolonged consumption of high fat diet primarilyaffects the liver thru the production of ROS that causes oxida......
自1995年报道cDNA编码的脂联素至今仅有10年时间,令医学界惊喜的发现接踵而来:人们研究发现它与肥胖、胰岛素抵抗、2型糖尿病及心......
胰岛素抵抗(Insulin Resistance,IR)作为糖尿病主要的病理生理特征,是遗传因素与环境因素共同作用的结果。IR作为糖尿病发病重要因......
Objectives To investigate the effect of telmisartan on human umbilical vein endothelial cells(HUVEC) exposed to high glu......
Nonalcoholic fatty liver disease(NAFLD)is quickly becoming one of the most prominent causes of liver disease worldwide.T......
1WhitehallⅡ研究“揭示2型糖尿病诊断前的代谢轨迹”;2荟萃分析“提供强化降糖有益于减少冠脉事件的证据”;3FIELD研究“非诺贝特......
目的:比较中药单体化合物小檗碱和噻唑烷二酮类药物罗格列酮对高脂饲料诱导大鼠非酒精性脂肪性肝炎(NASH)的干预作用,探讨小檗碱成......
目的观察姜黄素对油酸诱导的大鼠脂肪变性肝细胞模型过氧化物酶体增殖物活化受体-α(PPAR-α)启动子区的去甲基化作用。方法将大鼠......
目的:探讨2型糖尿病大鼠骨髓腔内过氧化物酶体增殖物激活受体γ(peroxisome prolifera-tor-activated receptor gamma,PPARγ)和核......
[目的]初步研究肥胖候选基因过氧化物酶增殖激活物受体-γ2(PPAR-γ2)基因Plo12Ala的变异以及解偶联蛋白2(UCP2)基因Ala55Val的变......
2,4,6-trinitrobenzene sulfonic acid-induced chronic colitis with fibrosis and modulation of TGF-β1 s
AIM:To investigate whether targeting proteasome might reverse intestinal fibrosis in rats.METHODS:Chronic colitis was in......
目的观察吡格列酮对创伤性脑损伤(TBI)大鼠过氧化物酶体增殖物激活受体γ(PPARγ)、肿瘤坏死因子α(TNF-α)、白细胞介素6(IL-6)mR......
英国科学家发现,一个名为“PPAR伽马”的基因发生变异后,会导致与血型糖尿病症状类似的罕见糖尿病。科学家说,该发现将有助于研制......
Synthesis of novel β-amino ketones containing a p-aminobenzoic acid moiety and evaluation of their a
The synthesis of two series of β-amino ketones containing a p-aminobenzoic acid moiety (TM-1 and TM-2) using a modified......
背景:雌二醇能否改变骨髓基质细胞分化过程中过氧化物酶增殖活化受体γ2-mRNA的表达进而影响其向成骨细胞分化有待研究。目的:观察......
目的:探讨中药复方三棱丸方对大鼠肠纤维化的治疗作用。方法:将48只SD大鼠随机均分为空白组、模型组、罗格列酮对照组、三棱丸方高......
目的:研究杨梅素(myricetin)对高脂膳食(HFD)诱导的C57BL/6小鼠肥胖的干预作用,并探讨其作用机理。创新点:首次在高脂膳食诱导的C5......
目的:探讨小檗碱对小鼠胚胎间充质干细胞C3H10t_(1/2)细胞增殖和成脂分化的影响。方法:采用MTS法对细胞增殖情况进行检测,同时通过......
Rosiglitazone inhibits expression of acyl-coenzyme A:cholesterol acyltransferase-1 in THP-1 macropha
Objective:To investigate the effects of rosiglitazone,a synthetic ligand of peroxisome proliferators-activated receptor ......
目的:从调控代谢酶角度探讨雷公藤复方配伍减轻雷公藤肝脏毒性的作用及分子机制。方法:SD大鼠给药1个月筛选雷公藤的肝毒性剂量;雷......
Telmisartan but not Valsartan Inhibits TGF-β-mediated Accumulation of Extracelluar Matrix via Activa
Glomerulosclerosis, defined as phenotype transition of mesangial cell and deposition of extracelluar matrix, remains a c......
过氧化物酶体增殖物激活受体(PPARs)是一类与糖脂代谢、胰岛素敏感性有关的核转录因子,激活PPARs靶标可以治疗由胰岛素抵抗引起的2......
Syringaresinol-4-O-β-D-glucoside alters lipid and glucose metabolism in HepG2 cells and C2C12 myotub
Syringaresinol-4-O-β-D-glucoside(SSG), a furofuran-type lignan, was found to modulate lipid and glucose metabolism thro......
子宫肌瘤是女性生殖系统最常见的良性肿瘤 ,生育年龄妇女中发病率为 2 0 %～ 30 % ,有报道可达 6 0 %～ 70 % ,但其病因及发病机理还不......
抵抗素是一种新的激素,在肥胖症与2型糖尿病之间可提供一种新的纽带关系,这种关系值得深入研究。2型糖尿病以胰岛素耐受和血糖水......
